Configure Windows for Maximum Layered Security

Windows OS updates and Patches

Run system as a Standard User

Any one Antivirus program free or paid

Malwarebytes Pro, and a on-demand Malware Scanner software

Data encryption software and password encryption software

Update to the latest version of your favorite browser

Firewalls protect the computer from outside intruders

behavior-monitoring layer ie: registry monitor, services, startup etc etc
Some sort of backup system