Polymorphic Malware

[Philip]

Hi Guys,
Is Polymorphic Malware typically detected and dealt with using typical Anti-Malware detection programs? Not always being up on the 'latest and greatest' topics this condition is new to me.
Currently

I'm not aware of this type of condition on my working system. I'm asking as a preventative measure.

If programs similar to Malware-bytes Pro doesn't doesn't detect such threats what is considered a good detection program that will detect such infections?

Thanks!